Tramadol trial completion

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Layout table for additonal information Responsible Party: Osvaldo A. Reyes T. Pain during labour Duration of labour Apgar score Umbilical cord pH.

National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Pain During Labour. Drug: Tramadol Drug: Placebo. Phase 3. Study Type :. Interventional Clinical Trial.

The escape latency against noxious ischaemia after morphine and amitriptyline administration did not change, despite an increase in dose, while increasing doses of tramadol mg kg -1 provided increasing analgesia against noxious ischaemia. As previously demonstrated, morphine was more potent than tramadol for the relief of thermal pain but tramadol may be a more beneficial drug for relieving severe ischaemic pain. Abstract The aim of this study was to compare the analgesic efficacies of tramadol, which acts on opioid receptors and inhibits monoamine reuptake, to amitriptyline, a monoamine reuptake inhibitor as well as to morphine, an opioid receptor agonist.